The series follows six Labrador/Golden Retriever puppies — Paco, Pacino, Raffi, Amara, Tulane, and Tartan — through their rigorous training to become Guide Dogs for the Blind. Each episode focuses on the transition from puppy raiser homes to professional training, highlighting the emotional bonds between the dogs, their volunteer raisers, and their eventual visually impaired partners. The series was a critical success for its heartwarming portrayal of the guide dog process.